Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal

Background Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD).The disturbance of hemodynamics can induce valvular calcification, lock shock and barrel art but the mechanism has not been fully identified.Methods We constructed a finite element model (FEM) of the aorti

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Expression dynamics of periodic transcripts during cancer cell cycle progression and their correlation with anticancer drug sensitivity

Abstract Background The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, read more among which transcriptional regulation is one of the most important components.Alternative splicing dramatically expands the regulatory network by producing transcript isoforms of genes to exquisitely control th

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